Background
In 333 BC Alexander the Great attempted to conquest Asia Minor. This triggered a chain of different reactions. He went from places in Asia minor like Pakistan and Kazakstan to places in Central Asia like India. He fought with many Asian nations and learned a lot from them. The Asians learned and adopted a lot of Greek culture. This was mostly learned through Major wars like the Battle of Grancius, and the Battle of Issus. This had a major short term and long term effect on both nations, and resinated for centuries after.
Alexander III (356-323 BC), or Alexander the Great was Macedonian king and son of Philip II of Macedon and an Epirote princess named Olympias. Alexander was tutored by Aristotle in science and the political arts, and he received a complete education in military tactics and strategy from the great Macedonian generals, Antipater and Parmenion. He had his first diplomatic experience while he was still a child, when he received the ambassadors of Persia during his father's absence. At the age of eighteen he led the Macedonian cavalry in a victorious charge which won the Battle of Chaeronea in 338 BC.Philip II was assassinated in 336 BC. just as he was about to lead a combined force of Greeks and Macedonians across the Hellespont to free the Greek states of Asia Minor from the Persians. The Greeks who where allies of Macedonia, were hoping they might erase some unpopular agreements made with Philip, but revolted in Thebes in 335 BC. Hearing of the Greeks, Alexander moved his army to Thebes within two weeks. The Thebans were a challenge, but Alexander breached their walls and overpowered them. To send a message to the other Greeks, Alexander destroyed all of Thebes, except for their temples. The remaining Greek states quickly offered ships and men for Alexander's next adventure, which was an attack on the Persians in Asia Minor. In the spring of 334 BC, Alexander crossed the Hellespont, defeating a strong Persian force at the Granicus River, and moved southward along the coast to free the major Greek cities of Aeolis and Ionia. (bio.com)